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A novel pThr217 tau monoclonal antibody reveals neuropathological heterogeneity in tauopathies

Abstract Tauopathies are a group of clinically and neuropathologically diverse neurodegenerative disorders defined by the abnormal aggregation of tau protein. While tau is normally soluble with limited secondary structure, pathological tau is characterized by hyperphosphorylation and assembly into f...

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主要な著者: Giavanna Paterno, Brach M. Bell, Kimberly-Marie M. Gorion, Stephan Quintin, Stefan Prokop, Benoit I. Giasson
フォーマット: Artigo
言語:Inglês
出版事項: Nature Portfolio 2025-06-01
シリーズ:Scientific Reports
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オンライン・アクセス:https://doi.org/10.1038/s41598-025-04291-y
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