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The impact of the human DNA topoisomerase II C-terminal domain on activity.

Type II DNA topoisomerases (topos) are essential enzymes needed for the resolution of topological problems that occur during DNA metabolic processes. Topos carry out an ATP-dependent strand passage reaction whereby one double helix is passed through a transient break in another. Humans have two topo...

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Hlavní autoři: Emma L Meczes, Kathryn L Gilroy, Katherine L West, Caroline A Austin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2008-03-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC2262138?pdf=render
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