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DDIT4/mTOR signaling pathway mediates cantharidin-induced hepatotoxicity and cellular damage

BackgroundCantharidin (CTD) extracted from the traditional Chinese medicine Mylabris has significant therapeutic effects on various tumors. However, the high toxicity of CTD can cause serious liver damage, although the related molecular mechanisms remain unclear.MethodsIn this study, we established...

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Principais autores: Wenchao Tang, Yue Pan, Can Zhu, Didong Lou, Fang Peng, Qin Shi, Yuanyuan Xiao
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-11-01
Serier:Frontiers in Pharmacology
Fag:
cantharidin
liver injury
DDIT4
mTOR signaling pathway
autophagy
apoptosis
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2024.1480512/full
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