Synthesis of Fused Quinoline Derivatives With Antiproliferative Activities and Tyrosine Kinases, Pim-1 Kinase Inhibitions

Cyclohexan-1,3-dione (1) reacted with either 2-aminoprop-1-ene-1,1,3-tricarbonitrile (2a) or diethyl 3-amino-2-cyanopent-2-enedioate (2b) to give the 5,6,7,8-tetrahydronaphthalene derivatives 3a and 3b, respectively. The latter compounds underwent further heterocyclization reactions to give the thie...

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Principais autores:	Rafat Milad Mohareb, Rehab Ali Ibrahim, Amira Mohamed Elmetwally, Marwa Soliman Gamaan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Slovenian Chemical Society 2022-03-01
Colecção:	Acta Chimica Slovenica
Assuntos:	cyclohexan-1,3-dione trichloroacetonitrile quinoline isoquinoline cytotoxicity
Acesso em linha:	https://journals.matheo.si/index.php/ACSi/article/view/6733
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