Limited Nrf2 activation and heterogeneous thyroidal effects in a 424-compound multi-assay screen call for rigorous testing of purported antioxidant and health-promoting supplements

We screened 424 natural compounds, including many marketed as dietary supplements, to assess their antioxidant and thyroidal effects. In rat PCCL3 thyroid follicular cells, we performed parallel primary screens for antioxidant response element (ARE) activation, thyroglobulin (Tg) promoter activity,...

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Hlavní autoři:	Georgios Psarias, Panos G. Ziros, Athina Mageiropoulou, Dionysios V. Chartoumpekis, George I. Habeos, Basil Mohammed Alomair, Leonidas Duntas, Ioannis P. Trougakos, Gerasimos P. Sykiotis
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-07-01
Edice:	Redox Biology
Témata:	Keap1-Nrf2 pathway Thyroid redox homeostasis Natural product library Nutritional supplements Thyroglobulin regulation Sodium-iodide symporter
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S221323172600220X
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