Limited Nrf2 activation and heterogeneous thyroidal effects in a 424-compound multi-assay screen call for rigorous testing of purported antioxidant and health-promoting supplements

We screened 424 natural compounds, including many marketed as dietary supplements, to assess their antioxidant and thyroidal effects. In rat PCCL3 thyroid follicular cells, we performed parallel primary screens for antioxidant response element (ARE) activation, thyroglobulin (Tg) promoter activity,...

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主要な著者:	Georgios Psarias, Panos G. Ziros, Athina Mageiropoulou, Dionysios V. Chartoumpekis, George I. Habeos, Basil Mohammed Alomair, Leonidas Duntas, Ioannis P. Trougakos, Gerasimos P. Sykiotis
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2026-07-01
シリーズ:	Redox Biology
主題:	Keap1-Nrf2 pathway Thyroid redox homeostasis Natural product library Nutritional supplements Thyroglobulin regulation Sodium-iodide symporter
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S221323172600220X
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