Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner.
HIV-1 does not persistently infect macaques due in part to restriction by several macaque host factors. This has been partially circumvented by generating chimeric SIV/HIV-1 viruses (SHIVs) that encode SIV antagonist of known restriction factors. However, most SHIVs replicate poorly in macaques unle...
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| Principais autores: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science (PLoS)
2019-07-01
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| Serier: | PLoS Pathogens |
| Online adgang: | https://doi.org/10.1371/journal.ppat.1007925 |
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