The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes

Macropinocytosis permits the cellular uptake of fluids and nutrients via macropinosomes. Here, the authors show that Phafin2 is required for the formation of macropinosomes and permits their transit through dense actin networks.

Bibliografiske detaljer

Principais autores:	Kay Oliver Schink, Kia Wee Tan, Hélène Spangenberg, Domenica Martorana, Marte Sneeggen, Virginie Stévenin, Jost Enninga, Coen Campsteijn, Camilla Raiborg, Harald Stenmark
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2021-11-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-021-26775-x
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