Short-term oral pre-exposure prophylaxis against HIV-1 modulates the transcriptome of foreskin tissue in young men in Africa

Whilst short-term oral pre-exposure prophylaxis (PrEP) with antiretroviral drugs in men who have sex with men has shown protection against HIV-1 infection, the impact of this regimen on the in vivo foreskin transcriptome is unknown. We collected foreskin tissue after voluntary medical male circumcis...

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Hlavní autoři:	Stefan Petkov, Carolina Herrera, Laura Else, Limakatso Lebina, Daniel Opoka, Thabiso B. Seiphetlo, Azure-Dee AP. Pillay, Susan Mugaba, Patricia Namubiru, Geoffrey Odoch, Andrew S. Ssemata, Jennifer Serwanga, Pontiano Kaleebu, Emily L. Webb, Saye Khoo, Neil Martinson, Clive M. Gray, Julie Fox, Francesca Chiodi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-11-01
Edice:	Frontiers in Immunology
Témata:	emtricitabine tenofovir pre-exposure prophylaxis PrEP transcriptomes inflammation foreskin mitochondrial function
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1009978/full
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