Hepatocyte membrane potential regulates serum insulin and insulin sensitivity by altering hepatic GABA release

Summary: Hepatic lipid accumulation in obesity correlates with the severity of hyperinsulinemia and systemic insulin resistance. Obesity-induced hepatocellular lipid accumulation results in hepatocyte depolarization. We have established that hepatocyte depolarization depresses hepatic afferent vagal...

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Bibliografiske detaljer

Principais autores:	Caroline E. Geisler, Susma Ghimire, Chelsea Hepler, Kendra E. Miller, Stephanie M. Bruggink, Kyle P. Kentch, Mark R. Higgins, Christopher T. Banek, Jun Yoshino, Samuel Klein, Benjamin J. Renquist
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2021-06-01
Serier:	Cell Reports
Fag:	obesity NAFLD hyperinsulinemia insulin resistance GABA GABA-transaminase
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2211124721006744
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