Inactivity-induced NR4A3 downregulation in human skeletal muscle affects glucose metabolism and translation: Insights from in vitro analysis

Objective: Physical activity promotes health, whereas inactivity is associated with metabolic impairment. The transcription factor nuclear receptor subfamily 4 group A member 3 (NR4A3) is a pleiotropic regulator of skeletal muscle exercise adaptation and metabolism. However, the consequence of lower...

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Detalhes bibliográficos

Principais autores:	Jonathon A.B. Smith, Brendan M. Gabriel, Aidan J. Brady, Ahmed M. Abdelmoez, Mladen Savikj, Shane C. Wright, Stefania Koutsilieri, Romain Barrès, Volker M. Lauschke, Anna Krook, Juleen R. Zierath, Nicolas J. Pillon
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-09-01
coleção:	Molecular Metabolism
Assuntos:	Skeletal muscle Inactivity Metabolism Mitochondria Protein synthesis
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2212877825001073
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