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Fragment-based discovery enables direct targeting of the melanoma oncogene MITF

Abstract Despite the improvement of therapeutic options, melanoma patients with advanced metastatic disease are still in high need of durable treatments. Analysis of clinical data from patients receiving targeted and/or immunotherapy, along with genetic and functional studies in preclinical melanoma...

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Main Authors: Deborah Castelletti, Jürgen Hinrichs, Goran Malojčić, Fei Ji, Aurore Desplat, Bryn Reimer, Christelle Henry, Kathryn A. Porter, Fanny Mermet-Meillon, Markus Wartmann, Emmanuelle Wirth, Cécile Delmas, César Fernández, Philipp H. O. Mayer, Niko Schmiedeberg, Simone Plattner, Jvan Brun, Stephan Kläusler, Jessica Kurmann, Kelly Yan, John Fuller, Fanny Schaeffer, Danilo Maddalo, Marc Altorfer, Nikoletta Piperidou, Nicolas Pautrieux, Frederic Baysang, Markus Kaufmann, Amanda Cobos-Correa, Rainer Wilcken, Martin Renatus, Anna Vulpetti, Wolfgang Jahnke
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2025-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-67297-0
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