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Golgi Fragmentation in Amyotrophic Lateral Sclerosis, an Overview of Possible Triggers and Consequences

Amyotrophic Lateral Sclerosis (ALS) is an invariably fatal neurodegenerative disorder, which specifically targets motor neurons in the brain, brain stem and spinal cord. Whilst the etiology of ALS remains unknown, fragmentation of the Golgi apparatus is detected in ALS patient motor neurons and in a...

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Guardado en:
Autores principales: Vinod eSundaramoorthy, Jessica M Sultana, Julie D Atkin
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2015-10-01
Colección:Frontiers in Neuroscience
Materias:
Amyotrophic Lateral Sclerosis
er stress
Axonal degeneration
Golgi fragmentation
secretory trafficking inhibition
autophagy dysfunction
Acceso en línea:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00400/full
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