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Heteroresistance is associated with mutations during low concentration of tigecycline therapy in multiple-resistant Klebsiella pneumoniae

Abstract Background Heteroresistance can lead to treatment failure and has brought a rigorous challenge to clinical laboratories for detecting them. The aim of this study was to investigate the potential for tigecycline-susceptible Klebsiella pneumoniae (K. pneumoniae) clinical isolates to develop h...

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Principais autores: Qiaoyu Zhang, Linwen Zheng, Lirong Wen, Shanshan Li, Yuli Nie, Jiansen Chen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-09-01
coleção:Annals of Clinical Microbiology and Antimicrobials
Assuntos:
Klebsiella pneumoniae
Tigecycline
Resistance
Heteroresistant
Evolution
Time-killing assay
Acesso em linha:https://doi.org/10.1186/s12941-025-00815-6
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