Discovery of potent tubulin inhibitors targeting the colchicine binding site via structure-based lead optimization and antitumor evaluation

The colchicine binding site of tubulin is a promising target for discovering novel antitumour agents. Previously, we identified 2-aryl-4-amide-quinoline derivatives displayed moderate tubulin polymerisation inhibitory activity and broad-spectrum in vitro antitumour activity. In this study, structure...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Wei Liu, Youyou He, Zhongjie Guo, Miaomiao Wang, Xiaodong Han, Hairui Jia, Jin He, Shanshan Miao, Shengzheng Wang
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Taylor & Francis Group 2023-12-01
श्रृंखला:	Journal of Enzyme Inhibition and Medicinal Chemistry
विषय:	Tubulin inhibitors colchicine binding site structural optimisation antitumour activity
ऑनलाइन पहुंच:	https://www.tandfonline.com/doi/10.1080/14756366.2022.2155815
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