Interaction of Colchicine-Site Ligands With the Blood Cell-Specific Isotype of β-Tubulin—Notable Affinity for Benzimidazoles

Tubulin, the main component of microtubules, is an α-β heterodimer that contains one of multiple isotypes of each monomer. Although the isotypes of each monomer are very similar, the beta tubulin isotype found in blood cells is significantly divergent in amino acid sequence compared to other beta tu...

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Үндсэн зохиолчид:	Felipe Montecinos, Maura Loew, Tak I. Chio, Susan L. Bane, Dan L. Sackett
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2022-05-01
Цуврал:	Frontiers in Cell and Developmental Biology
Нөхцлүүд:	tubulin isotypes beta tubulin erythrocytes colchicine benzimidazoles repurposing drugs
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fcell.2022.884287/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!