CCR-CCL axes as key upstream influencers of pancreatic ductal adenocarcinoma: CCR2–CCL2, CCR5–CCL5, CCR4–CCL17/22, CCR6–CCL20, CCR7–CCL19/21

PDAC remains one of the most lethal malignancies, characterized by a highly desmoplastic ECM that promotes an immunosuppressive signaling network and dampens the effectiveness of traditional therapies. Among the several key contributors to its immune evasion pathways are chemokine signaling axes, wh...

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Κύριος συγγραφέας:	Ingyu Bahng
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2026-01-01
Σειρά:	Frontiers in Immunology
Θέματα:	chemokine receptor antagonists chemokine signaling extracellular matrix (ECM) immune evasion pancreatic ductal adenocarcinoma (PDAC) tumor-associated macrophages (TAMs)
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1713123/full
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