Telomouse—a mouse model with human-length telomeres generated by a single amino acid change in RTEL1

Abstract Telomeres, the ends of eukaryotic chromosomes, protect genome integrity and enable cell proliferation. Maintaining optimal telomere length in the germline and throughout life limits the risk of cancer and enables healthy aging. Telomeres in the house mouse, Mus musculus, are about five time...

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Autors principals:	Riham Smoom, Catherine Lee May, Vivian Ortiz, Mark Tigue, Hannah M. Kolev, Melissa Rowe, Yitzhak Reizel, Ashleigh Morgan, Nachshon Egyes, Dan Lichtental, Emmanuel Skordalakes, Klaus H. Kaestner, Yehuda Tzfati
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2023-10-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-023-42534-6
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