Identification of spastic ataxia-related proteins via comparative proteomic analysis of the cerebellum of conditional Ankfy1 knockout mice

Abstract Ankyrin repeat and FYVE domain containing 1 (ANKFY1) is an indispensable protein in the development of cerebellar Purkinje cells. Our preliminary study revealed that its absence caused progressive spastic ataxia, accompanied by the loss of Purkinje cells in mice. Here, we generated Ankfy1-f...

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Principais autores:	Rong Fu, Man Ding, Tong Yin, Linlin Zheng, Yue Liu, Hang Yu, Rumeng Zhou, Zuneng Lu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-07-01
Series:	Scientific Reports
Assuntos:	Ankfy1 Purkinje cell Spastic ataxia Data-independent acquisition
Acceso en liña:	https://doi.org/10.1038/s41598-025-06398-8
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