Human spindle-shaped urine-derived stem cell exosomes alleviate severe fatty liver ischemia–reperfusion injury by inhibiting ferroptosis via GPX4

Abstract Background Severe hepatic steatosis can exacerbate Ischemia–reperfusion injury (IRI), potentially leading to early graft dysfunction and primary non-function. In this study, we investigated the heterogeneity of different subpopulations of Urine-derived stem cells (USCs) to explore the most...

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Ngā kaituhi matua:	Shangheng Shi, Cunle Zhu, Shangxuan Shi, Xinqiang Li, Imran Muhammad, Qingguo Xu, Xinwei Li, Ziyin Zhao, Huan Liu, Guangming Fu, Meiying Song, Xijian Huang, Feng Wang, Jinzhen Cai
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2025-02-01
Rangatū:	Stem Cell Research & Therapy
Ngā marau:	Urine-derived stem cells Heterogeneity Exosomes Ferroptosis Ischemia–reperfusion injury Fatty liver
Urunga tuihono:	https://doi.org/10.1186/s13287-025-04202-y
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