Leukocyte activation primes fibrinogen for proteolysis by mitochondrial oxidative stress

Critical illness leads to rapid fibrinogen consumption, hyperfibrinolysis, and coagulopathy that exacerbates bleeding and increases mortality. Immune cell activation and inflammation are associated with coagulopathy after injury but play an undetermined role. We performed high dimensional immunophen...

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מידע ביבליוגרפי

Principais autores:	Chang Yeop Han, Trey J. Pichon, Xu Wang, Kristyn M. Ringgold, Alexander E. St John, Susan A. Stern, Nathan J. White
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2022-05-01
סדרה:	Redox Biology
נושאים:	Coagulopathy Inflammation Fibrinogen Reactive oxygen species Oxidation Antioxidants
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2213231722000350
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