Leukocyte activation primes fibrinogen for proteolysis by mitochondrial oxidative stress

Critical illness leads to rapid fibrinogen consumption, hyperfibrinolysis, and coagulopathy that exacerbates bleeding and increases mortality. Immune cell activation and inflammation are associated with coagulopathy after injury but play an undetermined role. We performed high dimensional immunophen...

Descrición completa

Detalles Bibliográficos

Principais autores:	Chang Yeop Han, Trey J. Pichon, Xu Wang, Kristyn M. Ringgold, Alexander E. St John, Susan A. Stern, Nathan J. White
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2022-05-01
Series:	Redox Biology
Assuntos:	Coagulopathy Inflammation Fibrinogen Reactive oxygen species Oxidation Antioxidants
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2213231722000350
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!