Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model

Abstract Background Alzheimer’s disease (AD) patients exhibit memory disruptions and profound sleep disturbances, including disruption of deep non-rapid eye movement (NREM) sleep. Slow-wave activity (SWA) is a major restorative feature of NREM sleep and is important for memory consolidation. Methods...

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Prif Awduron:	Qiuchen Zhao, Megi Maci, Morgan R. Miller, Heng Zhou, Fang Zhang, Moustafa Algamal, Yee Fun Lee, Steven S. Hou, Stephen J. Perle, Hoang Le, Alyssa N. Russ, Eng H. Lo, Dmitry Gerashchenko, Stephen N. Gomperts, Brian J. Bacskai, Ksenia V. Kastanenka
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2023-12-01
Cyfres:	Molecular Neurodegeneration
Pynciau:	Optogenetics Microglia EEG Sleep Slow oscillations Alzheimer’s disease
Mynediad Ar-lein:	https://doi.org/10.1186/s13024-023-00682-9
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