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CD56bright NK cells are negatively associated with antibody response to vaccination in people with multiple sclerosis on B‐cell‐depleting therapy

Abstract Objectives We sought to identify determinants of vaccine response in people with multiple sclerosis (pwMS) receiving B‐cell‐depleting therapies. Methods This was a prospective single‐centre cohort study (ACTRN12623001249640). Peripheral blood samples were collected from pwMS receiving ocrel...

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Principais autores: Griffith B Perkins, Christopher M Hope, Cheng Sheng Chai, Matthew J Tunbridge, Sebastian Sterling, Kevin Webb, Joey Yap, Arthur Eng Lip Yeow, Makutiro G Masavuli, Jacqueline Scaffidi, James D Zuiani, Anouschka Akerman, Anupriya Aggarwal, Vanessa Milogiannakis, Matthew B Roberts, Plinio R Hurtado, Stuart Turville, Branka Grubor‐Bauk, Simon C Barry, Janakan Ravindran, Patrick Toby Coates, Pravin Hissaria
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2026-02-01
coleção:Clinical & Translational Immunology
Assuntos:
B‐cell depletion
CD56bright NK cells
multiple sclerosis
vaccination
virus neutralisation
Acesso em linha:https://doi.org/10.1002/cti2.70079
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