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Addition of polygenic risk score to a risk calculator for prediction of breast cancer in US Black women

Abstract Background Previous work in European ancestry populations has shown that adding a polygenic risk score (PRS) to breast cancer risk prediction models based on epidemiologic factors results in better discriminatory performance as measured by the AUC (area under the curve). Following publicati...

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Hauptverfasser: Gary R. Zirpoli, Ruth M. Pfeiffer, Kimberly A. Bertrand, Dezheng Huo, Kathryn L. Lunetta, Julie R. Palmer
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2024-01-01
Schriftenreihe:Breast Cancer Research
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Online-Zugang:https://doi.org/10.1186/s13058-023-01748-8
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