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Sequential Fibroblast Growth Factor Receptor Inhibition in Intrahepatic Cholangiocarcinoma: Navigating an Evolving Landscape of Resistance and Opportunity—A Case Report and Current Opinion

Abstract Fibroblast growth factor receptor ( FGFR ) 2 rearrangements define a distinct molecular subset of intrahepatic cholangiocarcinoma (iCCA) with therapeutic potential using FGFR inhibitors. However, acquired resistance invariably limits long-term efficacy, posing a significant clinical challen...

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Principais autores: Hideki Sasanuma, Hironori Yamaguchi
Format: Artigo
Sprog:Inglês
Udgivet: Adis, Springer Healthcare 2025-08-01
Serier:Oncology and Therapy
Fag:
Biliary tract cancer
Case report
Cholangiocarcinoma
FGFR inhibitor
FGFR2 rearrangement
Futibatinib
Online adgang:https://doi.org/10.1007/s40487-025-00371-1
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