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Understanding the Role of Anti-PEG Antibodies in the Complement Activation by Doxil in Vitro

Infusion reactions (IRs) are common immune-mediated side effects in patients treated with a variety of drug products, including, but not limited to, nanotechnology formulations. The mechanism of IRs is not fully understood. One of the best studied mechanisms of IRs to nanomedicines is the complement...

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Principais autores: Barry W. Neun, Yechezkel Barenholz, Janos Szebeni, Marina A. Dobrovolskaia
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2018-07-01
Serier:Molecules
Fag:
nanoparticles
liposomes
complement activation
CARPA
hypersensitivity
infusion reaction
immunotoxicity
anti-PEG antibody
Online adgang:http://www.mdpi.com/1420-3049/23/7/1700
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