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Lycii radicis cortex alleviates fibrosis in hiPSC-derived multilineage hepatic organoids via the cAMP-PKA pathway

BackgroundLiver fibrosis, driven by excessive extracellular matrix (ECM) deposition and activation of hepatic stellate cells (HSCs), still lacks effective therapies, partly due to the absence of human-relevant models. Lycii Radicis Cortex (LRC), a traditional Chinese medicine, exhibits reported anti...

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Príomhchruthaitheoirí: Junming Xu, Xiaopu Sang, Yongfei He, Jie Ke, Jiasen Xu, Tanbin Liu, Jicai Wang, Hang Zhai, Xiaoni Chen, Xianjie Shi, Fenfang Wu
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Frontiers Media S.A. 2025-11-01
Sraith:Frontiers in Pharmacology
Ábhair:
Rochtain ar líne:https://www.frontiersin.org/articles/10.3389/fphar.2025.1730255/full
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