Lycii radicis cortex alleviates fibrosis in hiPSC-derived multilineage hepatic organoids via the cAMP-PKA pathway

BackgroundLiver fibrosis, driven by excessive extracellular matrix (ECM) deposition and activation of hepatic stellate cells (HSCs), still lacks effective therapies, partly due to the absence of human-relevant models. Lycii Radicis Cortex (LRC), a traditional Chinese medicine, exhibits reported anti...

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Hlavní autoři:	Junming Xu, Xiaopu Sang, Yongfei He, Jie Ke, Jiasen Xu, Tanbin Liu, Jicai Wang, Hang Zhai, Xiaoni Chen, Xianjie Shi, Fenfang Wu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-11-01
Edice:	Frontiers in Pharmacology
Témata:	natural products IPSCs (induced pluripotent stem cells) organoid liver fibrosis lycii radicis cortex cAMP–PKA–CREB pathway
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1730255/full
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