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Hepatic and Extrahepatic Insulin Clearance in Mice with Double Deletion of Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide Receptors

The aim of this study was to investigate whether incretins, at physiological levels, affect hepatic and/or extrahepatic insulin clearance. Hepatic and extrahepatic insulin clearance was studied in 31 double incretin receptor knockout (DIRKO) and 45 wild-type (WT) mice, which underwent an Intravenous...

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Principais autores: Micaela Morettini, Agnese Piersanti, Laura Burattini, Giovanni Pacini, Christian Göbl, Bo Ahrén, Andrea Tura
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-08-01
coleção:Biomedicines
Assuntos:
insulin clearance
incretin hormones
animal model
DIRKO
IVGTT
mathematical model
Acesso em linha:https://www.mdpi.com/2227-9059/9/8/973
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