Downstream interaction by glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide agonism is required for synergistic effects on body weight

Objectives: Dual glucagon-like peptide-1 receptor and glucose-dependent insulinotropic polypeptide receptor agonists (GLP1RA and GIPRA, respectively) synergise to reduce body weight. Though this synergy depends on receptors within the brain, where and how this occurs is unclear. Methods: We employed...

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Autori principali:	Claire H. Feetham, Minrong Ai, Isabella Culotta, Alessia Costa, Jenna Hunter, Robert A. Brown, Tamer Coskun, Paul J. Emmerson, Giuseppe D'Agostino, Simon M. Luckman
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-09-01
Serie:	Molecular Metabolism
Soggetti:	Glucagon-like peptide-1 Glucose-dependent insulinotropic polypeptide Dual-incretin agonist Obesity Tirzepatide
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2212877825001218
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