Divergent resistance pathways amongst SARS-CoV-2 PLpro inhibitors highlight the need for scaffold diversity.

Drug-escape, where a target evolves to escape inhibition from a drug, has the potential to lead to cross-resistance where drugs that are structurally related or share similar binding mechanisms all become less effective. PLpro inhibitors are currently under development and many emerging PLpro inhibi...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Xinyu Wu, Shane M Devine, Margareta Go, Julie V Nguyen, Bernadine G C Lu, Katie Loi, Nathan W Kuchel, Kym N Lowes, Jeffrey P Mitchell, Guillaume Lessene, David Komander, Matthew E Call, Melissa J Call
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2025-09-01
Edice:	PLoS Pathogens
On-line přístup:	https://doi.org/10.1371/journal.ppat.1013468
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!