Divergent resistance pathways amongst SARS-CoV-2 PLpro inhibitors highlight the need for scaffold diversity.

Drug-escape, where a target evolves to escape inhibition from a drug, has the potential to lead to cross-resistance where drugs that are structurally related or share similar binding mechanisms all become less effective. PLpro inhibitors are currently under development and many emerging PLpro inhibi...

Полное описание

Библиографические подробности

Главные авторы:	Xinyu Wu, Shane M Devine, Margareta Go, Julie V Nguyen, Bernadine G C Lu, Katie Loi, Nathan W Kuchel, Kym N Lowes, Jeffrey P Mitchell, Guillaume Lessene, David Komander, Matthew E Call, Melissa J Call
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2025-09-01
Серии:	PLoS Pathogens
Online-ссылка:	https://doi.org/10.1371/journal.ppat.1013468
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!