CLEC12A signaling represses protective immune responses and contributes to hippocampal pathology in neurotropic picornavirus infection

Abstract Neurotropic viruses infect the central nervous system (CNS) and can cause severe neurological disorders. Theiler’s murine encephalomyelitis virus (TMEV) infection in C57BL/6 mice serves as a model for virus-induced encephalitis and hippocampal damage. C-type lectin domain family 12 member A...

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主要な著者:	M. K. Ameen, M. Stoff, S. Pavasutthipaisit, T. Ebbecke, M. Ciurkiewicz, T. Störk, J. Ruland, B. Lepenies, A. Beineke
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2025-11-01
シリーズ:	Scientific Reports
主題:	CLEC12A TMEV Neuroinflammation Hippocampal pathology Antiviral immunity C-type lectin receptor
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-27365-3
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