CLEC12A signaling represses protective immune responses and contributes to hippocampal pathology in neurotropic picornavirus infection

Abstract Neurotropic viruses infect the central nervous system (CNS) and can cause severe neurological disorders. Theiler’s murine encephalomyelitis virus (TMEV) infection in C57BL/6 mice serves as a model for virus-induced encephalitis and hippocampal damage. C-type lectin domain family 12 member A...

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Главные авторы:	M. K. Ameen, M. Stoff, S. Pavasutthipaisit, T. Ebbecke, M. Ciurkiewicz, T. Störk, J. Ruland, B. Lepenies, A. Beineke
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2025-11-01
Серии:	Scientific Reports
Предметы:	CLEC12A TMEV Neuroinflammation Hippocampal pathology Antiviral immunity C-type lectin receptor
Online-ссылка:	https://doi.org/10.1038/s41598-025-27365-3
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