Low dose Adenoviral Vammin gene transfer induces myocardial angiogenesis and increases left ventricular ejection fraction in ischemic porcine heart

Abstract This preliminary study investigated if VEGFR-2 selective adenoviral Vammin (AdVammin) gene therapy could induce angiogenesis and increase perfusion in the healthy porcine myocardium. Also, we determined using a clinically relevant large animal model if AdVammin gene therapy could improve th...

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Bibliografiske detaljer

Principais autores:	Niko Järveläinen, Paavo J. Halonen, Jussi Nurro, Antti Kuivanen, Juho Pajula, Miikka Tarkia, Maria Grönman, Antti Saraste, Johanna Laakkonen, Pyry Toivanen, Tiina Nieminen, Tuomas T. Rissanen, Juhani Knuuti, Seppo Ylä-Herttuala
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2024-12-01
Serier:	Scientific Reports
Online adgang:	https://doi.org/10.1038/s41598-024-81773-5
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