Low dose Adenoviral Vammin gene transfer induces myocardial angiogenesis and increases left ventricular ejection fraction in ischemic porcine heart

Abstract This preliminary study investigated if VEGFR-2 selective adenoviral Vammin (AdVammin) gene therapy could induce angiogenesis and increase perfusion in the healthy porcine myocardium. Also, we determined using a clinically relevant large animal model if AdVammin gene therapy could improve th...

Description complète

Détails bibliographiques

Auteurs principaux:	Niko Järveläinen, Paavo J. Halonen, Jussi Nurro, Antti Kuivanen, Juho Pajula, Miikka Tarkia, Maria Grönman, Antti Saraste, Johanna Laakkonen, Pyry Toivanen, Tiina Nieminen, Tuomas T. Rissanen, Juhani Knuuti, Seppo Ylä-Herttuala
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2024-12-01
Collection:	Scientific Reports
Accès en ligne:	https://doi.org/10.1038/s41598-024-81773-5
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!