Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage

Abstract Glucagon-like peptide 1 (GLP1), which is mainly processed and cleaved from proglucagon in enteroendocrine cells (EECs) of the intestinal tract, acts on the GLP1 receptor in pancreatic cells to stimulate insulin secretion and to inhibit glucagon secretion. However, GLP1 processing is not ful...

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Bibliografische Detailangaben

Hauptverfasser:	Ke Gong, Chao Xue, Zian Feng, Ruru Pan, Mengyao Wang, Shasha Chen, Yuanli Chen, Yudong Guan, Lingyun Dai, Shuang Zhang, Liwei Jiang, Ling Li, Bei Wang, Zequn Yin, Likun Ma, Yasuko Iwakiri, Junming Tang, Chenzhong Liao, Houzao Chen, Yajun Duan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-08-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-024-51352-3
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