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Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma

Abstract Background Glaucoma is characterized by the progressive dysfunction and loss of retinal ganglion cells. Recent work in animal models suggests that a critical neuroinflammatory event damages retinal ganglion cell axons in the optic nerve head during ocular hypertensive injury. We previously...

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Hoofdauteurs: Pete A. Williams, Catherine E. Braine, Krishnakumar Kizhatil, Nicole E. Foxworth, Nicholas G. Tolman, Jeffrey M. Harder, Rebecca A. Scott, Gregory L. Sousa, Alyssa Panitch, Gareth R. Howell, Simon W. M. John
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2019-01-01
Reeks:Molecular Neurodegeneration
Onderwerpen:
Glaucoma
Retinal ganglion cell
Optic nerve
Monocyte
Vascular leakage
Extravasation
Online toegang:http://link.springer.com/article/10.1186/s13024-018-0303-3
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