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Merging enzymes with chemocatalysis for amide bond synthesis

Proteins, other metabolites and many valuable synthetic products contain amide bonds and there is a need for more sustainable amide synthesis routes. Here the authors show an integrated next generation multi-catalytic system, merging nitrile hydratase enzymes with a Cu-catalysed N-arylation reaction...

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Autori principali: Luis Bering, Elliott J. Craven, Stanley A. Sowerby Thomas, Sarah A. Shepherd, Jason Micklefield
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2022-01-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-022-28005-4
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