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Merging enzymes with chemocatalysis for amide bond synthesis

Proteins, other metabolites and many valuable synthetic products contain amide bonds and there is a need for more sustainable amide synthesis routes. Here the authors show an integrated next generation multi-catalytic system, merging nitrile hydratase enzymes with a Cu-catalysed N-arylation reaction...

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Bibliografiske detaljer
Principais autores: Luis Bering, Elliott J. Craven, Stanley A. Sowerby Thomas, Sarah A. Shepherd, Jason Micklefield
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2022-01-01
Serier:Nature Communications
Online adgang:https://doi.org/10.1038/s41467-022-28005-4
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