Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade

Rheb, a ubiquitous small GTPase, is well known to bind and activate mTOR, which augments protein synthesis. Inhibition of protein synthesis is also physiologically regulated. Thus, with cell stress, the unfolded protein response system leads to phosphorylation of the initiation factor eIF2α and arre...

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Autors principals:	Richa Tyagi, Neelam Shahani, Lindsay Gorgen, Max Ferretti, William Pryor, Po Yu Chen, Supriya Swarnkar, Paul F. Worley, Katrin Karbstein, Solomon H. Snyder, Srinivasa Subramaniam
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2015-02-01
Col·lecció:	Cell Reports
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124715000273
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