Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

Abstract Tumour necrosis factor (TNF) signalling is mediated via two receptors, TNF-receptor 1 (TNFR1) and TNF-receptor 2 (TNFR2), which work antithetically to balance CNS immune responses involved in autoimmune diseases such as multiple sclerosis. To determine the therapeutic potential of selective...

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Autors principals:	Sarah K. Williams, Richard Fairless, Olaf Maier, Patricia C. Liermann, Kira Pichi, Roman Fischer, Ulrich L. M. Eisel, Roland Kontermann, Andreas Herrmann, Babette Weksler, Nacho Romero, Pierre-Olivier Couraud, Klaus Pfizenmaier, Ricarda Diem
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2018-09-01
Col·lecció:	Scientific Reports
Matèries:	TNF Receptor (TNFR1) Immune Cell Composition Central Nervous System Immune Cells Experimental Autoimmune Encephalomyelitis Anti-drug Antibodies (ADAs)
Accés en línia:	https://doi.org/10.1038/s41598-018-31957-7
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