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Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

Abstract Tumour necrosis factor (TNF) signalling is mediated via two receptors, TNF-receptor 1 (TNFR1) and TNF-receptor 2 (TNFR2), which work antithetically to balance CNS immune responses involved in autoimmune diseases such as multiple sclerosis. To determine the therapeutic potential of selective...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Sarah K. Williams, Richard Fairless, Olaf Maier, Patricia C. Liermann, Kira Pichi, Roman Fischer, Ulrich L. M. Eisel, Roland Kontermann, Andreas Herrmann, Babette Weksler, Nacho Romero, Pierre-Olivier Couraud, Klaus Pfizenmaier, Ricarda Diem
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2018-09-01
Schriftenreihe:Scientific Reports
Schlagworte:
TNF Receptor (TNFR1)
Immune Cell Composition
Central Nervous System Immune Cells
Experimental Autoimmune Encephalomyelitis
Anti-drug Antibodies (ADAs)
Online-Zugang:https://doi.org/10.1038/s41598-018-31957-7
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