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Chronic inflammation of middle ear cholesteatoma promotes its recurrence via a paracrine mechanism

Abstract Background Cholesteatoma disease is an expanding lesion in the middle ear. Hearing loss and facial paralysis alongside with other intracranial complications are found. No pharmaceutical treatment is available today and recurrence after surgical extraction occurs. We investigated possible TL...

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Principais autores: Matthias Schürmann, Felix Oppel, Senyao Shao, Verena Volland-Thurn, Christian Kaltschmidt, Barbara Kaltschmidt, Lars-Uwe Scholtz, Holger Sudhoff
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-02-01
Serier:Cell Communication and Signaling
Fag:
Cholesteatoma
Inflammation
TLR4
Stem cells
Cholesteatoma recurrence
Online adgang:https://doi.org/10.1186/s12964-020-00690-y
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