Proneurotrophin-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons

Abstract Cancer patients undergoing treatment with antineoplastic drugs often experience chemotherapy-induced neuropathic pain (CINP), and therapeutic options for managing CINP are limited. Here, we show that systemic paclitaxel administration upregulates the expression of neurotrophin-3 (Nt3) mRNA...

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Detalhes bibliográficos

Principais autores:	Dilip Sharma, Xiaozhou Feng, Bing Wang, Huijie Shang, Bushra Yasin, Alex Bekker, Huijuan Hu, Yuan-Xiang Tao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2025-11-01
Colecção:	EMBO Reports
Assuntos:	Proneurotrophin-3 TrkC C-C Chemokine Ligand 2 Paclitaxel-induced Peripheral Neuropathy Dorsal Root Ganglion
Acesso em linha:	https://doi.org/10.1038/s44319-025-00534-1
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