RNA-binding protein MBNL2 mitigates neuropathic pain after chemotherapy through destabilizing CCR2 expression in primary sensory neurons

Chemotherapy drug-induced changes of gene expression in the dorsal root ganglion (DRG) are critical for the genesis of chemotherapy-induced neuropathic pain (CINP). However, the mechanisms driving these changes remain elusive. Here, we report the downregulation of muscleblind-like protein 2 (MBNL2),...

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Autores principales:	Keshi Yan, Ruining Ma, Bing Wang, Xiaozhou Feng, Xinju Li, Xianglei Meng, Huijie Shang, Benjamin M. Kidd, Maurice S. Swanson, Huijuan Hu, Yuan-Xiang Tao
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2026-04-01
Colección:	Neurotherapeutics
Materias:	Muscleblind-like protein 2 C–C chemokine receptor type 2 Paclitaxel Dorsal root ganglion And chemotherapy-induced neuropathic pain
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S1878747926000759
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