A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation.

Endoplasmic reticulum-associated degradation (ERAD) is a protein quality control pathway of fundamental importance to cellular homeostasis. Although multiple ERAD pathways exist for targeting topologically distinct substrates, all pathways require substrate ubiquitination. Here, we characterize a ke...

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Detalhes bibliográficos

Principais autores:	Christopher E Smith, Yien Che Tsai, Yu-He Liang, Domarin Khago, Jennifer Mariano, Jess Li, Sergey G Tarasov, Emma Gergel, Borong Tsai, Matthew Villaneuva, Michelle E Clapp, Valentin Magidson, Raj Chari, R Andrew Byrd, Xinhua Ji, Allan M Weissman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2021-12-01
coleção:	PLoS Biology
Acesso em linha:	https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001474&type=printable
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