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MK8722 alleviates osteoarthritis by activating Sesn2 and transcriptionally upregulating BNIP3 to promote mitophagy and inhibit chondrocyte ferroptosis

Introduction: Osteoarthritis (OA) is commonly accompanied by irreversible destruction of articular cartilage and is difficult to effectively relieve, primarily due to the unclear pathogenesis and the lack of effective therapeutic interventions. Sestrin 2 (Sesn2) is a highly conserved protein that re...

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Main Authors: Haochen Wang, Ze Zhao, Jianbang Su, Wenzheng Chen, Haoyan Shi, Tianqi Gao, Minghao Yu, Lunhao Bai, Peng Dong, Qian Zhang, Chao Ji, Jingyu Yang, Yang Liu, Yingliang Wei
Format: Artigo
Language:Inglês
Published: Elsevier 2026-06-01
Series:Journal of Advanced Research
Subjects:
Osteoarthritis
Sesn2
MK8722
Mitophagy
Ferroptosis
BNIP3
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123225007647
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