MK8722 alleviates osteoarthritis by activating Sesn2 and transcriptionally upregulating BNIP3 to promote mitophagy and inhibit chondrocyte ferroptosis

Introduction: Osteoarthritis (OA) is commonly accompanied by irreversible destruction of articular cartilage and is difficult to effectively relieve, primarily due to the unclear pathogenesis and the lack of effective therapeutic interventions. Sestrin 2 (Sesn2) is a highly conserved protein that re...

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Hlavní autoři:	Haochen Wang, Ze Zhao, Jianbang Su, Wenzheng Chen, Haoyan Shi, Tianqi Gao, Minghao Yu, Lunhao Bai, Peng Dong, Qian Zhang, Chao Ji, Jingyu Yang, Yang Liu, Yingliang Wei
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-06-01
Edice:	Journal of Advanced Research
Témata:	Osteoarthritis Sesn2 MK8722 Mitophagy Ferroptosis BNIP3
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2090123225007647
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